Interaction of Common Azole Antifungals with P Glycoprotein
نویسندگان
چکیده
منابع مشابه
Cyclophosphamide metabolism is affected by azole antifungals.
We performed a randomized trial to compare the safety and efficacy of itraconazole with fluconazole in preventing fungal infections in patients undergoing allogeneic stem cell transplantation (SCT). Itraconazole (intravenous 200 mg daily, or oral solution 2.5 mg/kg 3 times daily) and fluconazole (intravenous or oral, 400 mg daily) were administered with the start of conditioning therapy, until ...
متن کاملMutation in cytochrome P-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals.
Young, 0. & Beevers, H. ( 1976) I’hy/ochrrnistry 15,379-385 19,525-530 Received 20 July I989 Taton, M., Ullmann, P.. Benveniste. P. & Rahirr. A. (1988) I’estic. Biochern. I’hysiol. 30, 178189 Trzaskos, J. M., Fisher, R. T. & Favata, M. F. (1986) J. Hie/. Chern. 261, 16937-16942 Jefcoate, C. R. ( 1978) in Methods in Enzvrnology (Fleischer. S. & Packer, L.. eds.), vol. 52, pp. 258, Academic Press...
متن کاملManagement of Drug-Drug Interaction between Everolimus and Azole Antifungals in a Cardiac Transplant Patient
A 64-year-old Caucasian male was admitted to the infectious disease department in May 2016 for exploration of a febrile syndrome lasting for two months associated with chronic cough for 1 year. He was treated by Everolimus (Certican®) 1 mg bid since 2011 as anti-rejection drug after cardiac transplantation in 1990. His treatment also included Atorvastatin 10mg/d, Ezetimibe 10mg/d, Prasugrel 10m...
متن کاملInteraction of antiepileptic drugs with human P-glycoprotein in vitro.
About one-third of epilepsy patients are resistant to treatment with antiepileptic drugs (AEDs). This refractoriness is not fully understood, but is thought to be attributed to overexpression of multidrug transporters at the blood-brain barrier, particularly P-glycoprotein (Pgp). In certain cases pharmacoresistance can be overcome by add-on therapy, raising the question of whether the coadminis...
متن کاملInteraction of imatinib mesilate with human P-glycoprotein.
The interaction of imatinib mesilate with P-glycoprotein (P-gp) was examined using pig kidney epithelial LLC-PK1 cells versus L-MDR1 cells, which overexpress human P-gp on the apical membrane. The basal-to-apical transport of imatinib mesilate in L-MDR1 cells significantly exceeded that in the parental LLCPK1 cells. The intracellular accumulation of imatinib mesilate after its basal application...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2002
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.46.1.160-165.2002